To replicate our findings, we applied the DGN elastic net whole blood prediction models to an independent rheumatoid arthritis GWAS from Vanderbilt University’s BioVU repository (see Materials and Methods). Both genes (DCLRE1B and PTPN22) that were found to be genome-wide significant in the WTCCC rheumatoid arthritis data were also significant, with concordant direction of effect, in the replication samples (p = 0.012 and p = 0.036, respectively).
