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Chunk #23 — DISCUSSION

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Polygenic dissection of major depression clinical heterogeneity.
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as that for schizophrenia, may lead to an even larger amount of variance explained in MDD liability by MDD GPRS. These results confirmed that the predictive accuracy of GPRS should be always interpreted in light of the genetic characteristics of the specific trait and the size of the discovery sample; any attempt to frame findings from different GPRS in terms of simple direct comparisons between each other should be avoided.