While we hypothesized that SOB effects on behavior are related to dopamine-melatonin changes, with our dataset it is not possible to clearly distinguish the underlying basis for the behavioral effects of SOB. While the SSS has been related to the DA system, it has also been related to other neurotransmitters, enzymes and hormones [reviewed in 97]. However, the associations revealed when SOB and genotype were included in the same models tentatively suggests that SOB does impact the dopamine system.