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Chunk #0 — Introduction

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Development of large-scale functional brain networks in children.
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Understanding the development of human brain organization is critical for gaining insight into brain organization and functions in adulthood as well as for investigating disorders such as autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD), where normal developmental processes are disrupted. Neuroimaging studies of development have primarily focused on structural changes from childhood, to adolescence, and into adulthood. These studies have reported age-related changes in (1) overall brain volumes [1],[2], (2) volumes of individual brain areas [3],[4], (3) regional cortical thickness [5],[6], as well as (4) regional and global grey-matter and white-matter densities [7]–[9]. Collectively these studies have suggested that the human brain undergoes vast developmental changes in grey and white matter structure between childhood and adulthood. These changes are thought to reflect synaptic pruning and myelination observed at the neuronal level [8],[9]. More recently, diffusion tensor imaging (DTI) studies investigating the development of white-matter pathways have shown increase in anisotropy [10]–[12], decrease in overall diffusion [13], and maturation in major white-matter fiber tracts [14]–[19], with age. In spite of growing evidence from these studies for patterned brain development, the