Chunk #3 — Results

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Tobacco smoking is associated with methylation of genes related to coronary artery disease.

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yes

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Characteristics of the participants under study are summarized in Table 1. Of the 724 subjects in the study, 195 were current smokers and 201 were never smokers. The mean age was 59.9 years. Among the current smokers, 50 % was male, among the never smoker 37 % (p = 0.008).Table 1Characteristics of study populationTotalCurrent smokersFormer smokersNever smokers p-valuea N724195319210Age (years)59.9 (8.2)58.1 (6.7)61.5 (8.6)59.2 (8.4)0.15Sex (male)334 (46 %)98 (50 %)155 (49 %)78 (37 %)0.008BMI (kg/m2)27.6 (4.6)26.8 (4.3)28.0 (4.5)27.7 (4.9)0.05Proportion CD8+ T-cellsb 0.09 (0.05)0.10 (0.05)0.09 (0.06)0.10 (0.05)0.81Proportion CD4+ T-cellsb 0.26 (0.08)0.27 (0.07)0.26 (0.08)0.26 (0.08)0.33Proportion NK cellsb 0.14 (0.06)0.11 (0.06)0.14 (0.06)0.14 (0.06)<0.001Proportion B-cellsb 0.10 (0.04)0.10 (0.04)0.10 (0.03)0.10 (0.04)0.59Proportion monocytesb 0.08 (0.03)0.08 (0.03)0.08 (0.03)0.08 (0.03)0.55Proportion granulocytesb 0.37 (0.11)0.38 (0.11)0.37 (0.12)0.37 (0.11)0.12Nr. erythrocytes (109/L)4.90 (0.37)4.86 (0.36)4.93 (0.37)4.88 (0.38)0.67Nr. platelets (109/L)283.8 (63.9)293.2 (69.3)280.2 (61.0)280.4 (62.4)0.05Fasting (yes)c 717 (99 %)192 (99 %)315 (99 %)210 (100 %)0.07Alcohol (g/day)18.2 (11.3)19.3 (12.8)18.9 (11.5)16.0 (8.9)0.002RNA quality score8.38 (0.51)8.36 (0.50)8.39 (0.49)8.38 (0.54)0.66Type 2 diabetes mellitus53 (7.3 %)7 (3.6 %)34 (10.6 %)12 (5.7 %)0.31Total cholesterol (mmol/L)5.6 (1.3)5.6 (1.1)5.6 (1.5)5.6 (1.1)0.88Triglycerides (mmol/L)1.49 (0.87)1.68 (1.14)1.43 (0.68)1.39 (0.80)0.005Systolic blood pressure (mmHg)135.7 (61.7)132.3 (61.7)137.5 (64.3)136.3 (57.6)0.50Diastolic blood