To investigate the relation between beta/HFO PAC and severity of motor impairment in more detail, we analysed a large cohort of patients for whom we acquired LFP recordings from the STN in combination with simultaneous magnetoencephalography (MEG). Using hemibody bradykinesia/rigidity UPDRS scores, we were able to demonstrate a significant correlation for both beta band power and PAC in the STN. In addition, we provide further evidence for a functional subdivision between low- and high-beta frequencies by comparing patterns of phase–amplitude coupling within the STN and beta band coherence between STN and ipsilateral motor cortex.
