TUD was also genetically associated with 59 other psychiatric and medical conditions (Figure 5b, Supplementary Table 31). There were significant positive rg with psychiatric traits (e.g., externalizing rg=0.71, SE=0.02; ADHD rg=0.50, SE=0.03; posttraumatic stress disorder rg=0.31, SE=0.08) and risky behavioral traits, including younger age of first sex (rg=−0.50, SE=0.03). We also found positive rg with health outcomes (e.g., coronary artery disease rg=0.26, SE=0.03; waist-to-hip ratio rg=0.26, SE=0.02; multisite chronic pain rg=0.36, SE=0.03) and several social determinants of health, such as the Townsend deprivation index (rg=0.61, SE=0.07). There were negative rg with socioeconomic variables, including educational attainment (rg=−0.53, SE=0.02) and household income (rg=−0.49, SE=0.03) and with intelligence (rg=−0.28, SE=0.02). Conditioning on alcohol, cannabis, or opioid use disorder did not substantially modify the magnitude or direction of these associations (Supplementary Table 32). Virtually all rg estimates for other phenotypes were greater with TUD than cigarettes per day (Figure 5c) and FTND (Figure 5d), but not smoking initiation (Figure 5e).
