Following the workshop, the NIH released a formal Request for Information (RFI) at https://grants.nih.gov/grants/guide/notice-files/NOT-DA-14-014.html and held a satellite symposium meeting summary at https://addictionresearch.nih.gov/sfn-meeting-summary the annual Society for Neuroscience meeting in Washington, D.C. to obtain broader input from extramural researchers and other public stakeholders on all aspects of the study—including optimal sample size and sampling strategies; approaches for replication of findings; the most appropriate neurocognitive, behavioral, and neuroimaging measures; methods for biospecimen collection and analyses; and arrangements for data sharing. While the scientific community was not in complete agreement on all of these areas, their input was vital to creating a framework for the development and release of the FOAs in January 2015. There was a robust response to these announcements in which applicants proposed study designs and specific measures that would address the research questions outlined in the FOAs within the overarching framework. Applications underwent NIH peer review during the summer and awards were made in September 2015.
