this area. It is conceivable that a more broadly-based AGRS that included additional variants implicated by bupropion’s pharmacology would have improved the ability of the AGRS to moderate treatment. As sufficient sample sizes are gathered to allow more atheoretical variant finding approaches such as genome wide association and next generation sequencing to be performed, the utility of the AGRS approach will be further enhanced as currently unidentified variants may be added to the score. As further refinements are made in disentangling single genetic markers with reliable effects on smoking related phenotypes (eg, bupropion response), the utility of the AGRS approach will potentially increase.
