Recall that the Nyholt threshold for a significant p-value for the two genetic factor scores is p<0.005. Of the thirty-one SNPs genotyped across DRD2/ANKK1, one SNP (rs10891549) showed significant association with the general alcohol consumption and problems factor score (p=0.004). Four SNPs (rs10891549, rs1554929, rs6275, rs6279) showed significant association with the alcohol problems genetic factor score (p=0.005, p=0.005, p=0.003, p=0.003, respectively). These results are detailed in Table 1. In addition, we conducted post hoc analyses in which we examined the association between DRD2/ANKK1 SNPs and the individual seven phenotypic measures of alcohol consumption and problems. These results are detailed in Table 2. Recall that the Nyholt corrected p-value for the seven alcohol outcomes is p<0.001. Using this criterion, none of the DRD2/ANKK1 SNPs were significantly associated with any of the individual alcohol measures.
