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Chunk #27 — Discussion

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Effects of chronic intermittent ethanol exposure and withdrawal on neuroblastoma cell transcriptome.
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decreased, which could mean less uptake of GABA and more activity. Decreased expression of SLC6A11/GAT3 in sweet drinking rats caused them to increase their intake of ethanol, and SLC6A11 was decreased in expression in the amygdala of post-mortem brains (Augier et al., 2018). In CIE treated P rats, the GABA, serotonin, and glutamate pathways were strongly affected, especially in the dorsal raphe nucleus (McClintick et al., 2015, 2016, 2018). In the DRN there were large decreases in most of the genes of the serotonin pathway, and more subtle changes in glutamate and GABA subunits.