(Fig. 3a and Supplementary Tables 2,3). The properties of the Cortex-EUR cis-eQTLs conform to studies performed in blood14 and brain15: primary lead cis-eQTL single nucleotide polymorphisms (SNPs) were generally located close to the TSS (median distance, 33.6 kilobases (kb)) and cis-eQTL genes had a lower probability for loss-of-function intolerance (pLI > 0.9; χ2 P = 2.48 × 10−83). Genes with a cis-eQTL generally had a higher median expression (Wilcoxon P = 5.5 × 10−174; Fig. 3b); the other properties of cis-eQTLs were very comparable with earlier reports (Supplementary Note, Supplementary Fig. 11 and Supplementary Table 4).
