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Chunk #4 — Introduction

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Lipid environment modulates the development of acute tolerance to ethanol in Caenorhabditis elegans.
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This study is designed to identify the molecular mechanisms for the development of AFT. Here, we report that an unbiased genetic screen for modulators of the development of AFT yielded genes involved in determining levels of triacylglycerols in the animal. Our data support a conclusion that the lipid environment is important in the ability of the animal to modify cell function in the development of AFT to ethanol.