levels that are not reflected in either accessibility or methylation.Megabase-scale regions with distinct epigenomic signatures show strong differences in activity, gene density, and nuclear lamina associations, suggesting distinct chromosomal domains.Approximately 5% of each reference epigenome shows enhancer and promoter signatures, which are 2-fold enriched for evolutionarily-conserved non-coding elements on average.Dynamics of epigenomic marks in their relevant chromatin states allow a data-driven approach to learn biologically-meaningful relationships between cell types, tissues, and lineages.Enhancers with coordinated activity patterns across tissues are enriched for common gene functions and human phenotypes, suggesting they represent coordinately-regulated modules.Regulatory motifs are enriched in tissue-specific enhancers, enhancer modules, and DNA accessibility footprints, providing an important resource for gene-regulatory studies.Genetic variants associated with diverse traits show epigenomic enrichments in trait-relevant tissues, providing an important resource for understanding the molecular basis of human disease.
