with the DIGS. This sample was a subsample of the one published in 2013 that included 418 patients from France and 169 patients from Norway13. For this study, only patients from France were included and the inclusion was based only on availability of DNA samples. No other exclusion criteria were used (in particular clinical ones). Written informed consent was obtained from all participants. This study was approved by the medical ethics committee of the French << Comité de Protection des Personnes (CPP) >> (IDRCB2008_AO1465_50 VI—Pitié Salpêtrière 118-08) and carried out in accordance with the approved guidelines.
