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Chunk #6 — MATERIALS AND METHODS — Human sample

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Antenatal prediction of postpartum depression with blood DNA methylation biomarkers.
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32 women euthymic during the third trimester (prepartum euthymic), 34.4% of this subsample (N=11) became depressed within the first 4 weeks postpartum and met the DSM-IV criteria for major depressive episode. A second subgroup of 19 women depressed during pregnancy (prepartum depressed) was assessed in subsequent analyses as an independent replication cohort, of which N=12 remained depressed within the first 4 weeks postpartum and met the DSM-IV criteria for major depressive episode. The trimester of blood draw is depicted in Supplementary Table 1.