Finally we calculated Bayesian probability of relevance for the combined, multivariate phenotype using all three measured phenotypes: lifetime depression, BSI depression score, and BSI anxiety score. Our results demonstrated moderate probability of relevance (Pr = 0.3–0.5) of 5-HTTLPR in both age groups (Fig. 3A) and childhood adversity groups (Fig. 3B), in those who had high recent negative life events. In addition, in the younger age group (≤30) 5-HTTLPR was strongly relevant in those who had medium or high childhood adversity and even moderate number of recent negative life events (Pr = 0.91 and Pr = 0.69 in moderate and high RLE groups, respectively; Fig. 3C), while in the older age group (>30) 5-HTTLPR was strongly relevant only in those who had high recent negative life events but this effect was present irrespective of childhood adversity (Pr = 0.91 and Pr = 0.82 in low and medium-high CHA groups, respectively; Fig. 3D).
