Chunk #19 — RESULTS — Inducible knockdown of T (brachyury) during mesendoderm differentiation of hPSCs

Source

Optimized inducible shRNA and CRISPR/Cas9 platforms for in vitro studies of human development using hPSCs.

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Collectively, these results strikingly recapitulate the known role of T during early embryonic development, thereby demonstrating the versatility of OPTiKD platforms to study the mechanisms of human development in vitro.