Chunk #25 — Results — Deleting Zfhx1b in SVZ of the MGE Using DlxI12b-Cre Phenocopies Loss of Zfhx1b function in the VZ (Nkx2.1-Cre) — Postnatal Analysis of cortical and striatal interneuron phenotypes in Nkx2.1-Cre;Zfhx1b mutants
We also analyzed the gross morphological properties of nNos/NPY/Sst striatal interneurons in the Zfhx1b mutant, and found that, like control brains, Zfhx1b conditional mutants had Sst processes restricted to the matrisomes (Chesselet and Graybiel, 1986), in a lateral to medial gradient (Figure S4G-S4I’- arrowheads mark CB-poor striosomes), suggesting that the overproduced nNos/NPY/Sst interneurons in the Zfhx1b conditional mutant share grossly similar morphological properties with wildtype striatal interneurons.
