Finally, we examined whether the buffering effect of rs1049353 on MDD was only observed in those with anhedonic depression. Consistent with the primary sample, rs1049353 interacted with the factor representing childhood physical abuse to predict anhedonic depression (Table 2, Figure 1, p-value=0.0077). Hence, the replication confirmed not only the stress-buffering effects of rs1049353 on the relationship between childhood physical abuse and anhedonia, but also attributed any effect of this interaction on MDD to presence of anhedonia.
