(strongest associated SNP: rs7563362, β = -0.36, p = 1.76x10-8) and FANCL loci (strongest associated SNP: rs980183, β = -0.26, p = 2.73x10-8). None of the SNPs that were originally reported were the top SNP in our data. However, for these three regions (S5A and S5B Fig, S2 Table), our top SNPs showed strong LD with the original reported SNPs (FTO locus: r-sq = 0.97 for rs55872725 and rs1558902; TMEM18 locus: r-sq = 1.00 for rs7563362 and rs13021737; FANCL locus: r-sq = 0.72 for rs980183 and rs1016287). Using a significance level of p = 0.05, 59% (19/32) known BMI SNPs [53], showed association with BMI in our data. In addition, 31 out of the 32 known SNPs showed associations in the same direction as the original BMI study (Fig 5).
