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Chunk #18 — Materials and methods — Hypothesis testing — Logistic regression testing

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Uncovering hidden variance: pair-wise SNP analysis accounts for additional variance in nicotine dependence.
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All the top SNP-pairs identified by the RPM were evaluated using logistic regression to determine if the signals could be identified by this alternative analytic method. The SNPs were treated as class variables. Results from univariate models and joint models with and without an interaction term were compared. Logistic regression analyses were performed using SAS® software version 9.1 (SAS Institute Inc., Cary, NC).