For LD Score regression, we excluded variants with EUR MAF < 1% because the LD Score standard errors for these variants were very high (note: variants included in LD Score regression are a subset of variants included in LD Score estimation). In addition, we excluded loci with extremely large effect sizes or extensive long-range LD from all regressions, because these can be considered outliers in such an analysis and would have disproportionate influence on the regression (Online Methods).
