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Chunk #28 — Results — BK mRNA splice variants encode channels with varied alcohol responsiveness

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Posttranscriptional regulation of BK channel splice variant stability by miR-9 underlies neuroadaptation to alcohol.
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Native current density differed among isoforms similarly to acute alcohol sensitivity, which contrasted ALCOREX and INSERTLESS with STREX (Figure 6D, Controls). ALCOREX and INSERTLESS BK channels had similar current density (65 pA/pF ± 13 pA/pF, 59 pA/pF ± 9 pA/pF, respectively), while STREX current density was lower (30 pA/pF ± 8 pA/pF) (Figure 6D).