(main effect of rs31746, P < 0.02). The effect was also consistent among EA and AA subjects when the two groups were analyzed separately (EA genotype by time point interaction for BQSU: F(1,85)= 2.87, P = 0.094; AA genotype by time point interaction for BQSU: F(1,88)= 2.88, P = 0.093). The average percent reduction in total BQSU score by rs31746 genotype was similar for EA subjects (30% for AA, 19% for AG, and 16% for GG) and AA subjects (34% for AA, 19% for AG, and 10% for GG).