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Chunk #18 — Results — Rs31746 is associated with smoking urges in smokers following overnight abstinence and intravenous nicotine infusion

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A protocadherin gene cluster regulatory variant is associated with nicotine withdrawal and the urge to smoke.
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(main effect of rs31746, P < 0.02). The effect was also consistent among EA and AA subjects when the two groups were analyzed separately (EA genotype by time point interaction for BQSU: F(1,85)= 2.87, P = 0.094; AA genotype by time point interaction for BQSU: F(1,88)= 2.88, P = 0.093). The average percent reduction in total BQSU score by rs31746 genotype was similar for EA subjects (30% for AA, 19% for AG, and 16% for GG) and AA subjects (34% for AA, 19% for AG, and 10% for GG).