With the recent directive from NIH to consider sex as a variable of interest in preclinical studies, the best way to approach it in human genetic studies is not yet clear. Many investigators (and grant reviewers) still believe strongly that reducing sample size by dividing the sample is not a good option. We hope this commentary will serve as a starting point for these investigators to reconsider this stance, and that they will be involved in developing strategies to evaluate and report the impact of sex in their work. Until best practices for considering sex in human genetic studies are developed and refined, there are some steps that can be taken now.
