A number of SNPs in the promoter region of the CRP gene have been shown to affect changes in transcription factor binding and gene promoter activity.[17], [32] The triallelic SNP has been associated with increased promoter activity and higher CRP levels,[32] and haplotypes of the promoter triallelic and rs3093032 SNPs affect transcription factor binding, transcriptional activity, and CRP levels.[17] The major alleles of 3872C>T and 5237A>G together serve as a proxy for the triallelic,[9] and the 2-SNP haplotype was associated with higher CRP levels in our studies as well as in others.[9], [23], [32] Otherwise, more functionality data are needed for CRP SNPs.
