Finally, future studies should include diagnostic interviews to document abuse/dependence and also examine comorbid anxiety disorders. Furthermore, future studies are needed to determine whether these SNPs may be associated with differential sensitivity to the acute effects of marijuana. Previous studies have suggested that sensitivity to marijuana plays an important role in the development of marijuana use problems [50,51]. Clearly, the subjective experience of marijuana use in terms of changes in mood, euphoria and reward may play an important role in the trajectory of marijuana use. It stands to reason that SNPs that alter either the regulation of cannabinoid signaling (e.g. the FAAH SNP) or create an alternative form of the CB1 receptor (e.g. the CNR1 SNP) may also alter the subjective effects of marijuana use. Future research needs to examine these genetic variables in the context of marijuana administration in order to determine whether these SNPs alter the acute effects of marijuana use.
