Significant departures from additivity in the odds for alcohol dependence were found in the relationship of parental history and sexual abuse, physical abuse and emotional neglect, controlling for demographics and other adverse experiences (p<0.05). As shown in Table 3, among individuals with a parental history of alcoholism and history of maltreatment, the proportion of alcohol dependence attributable to the interaction between the maltreatments and parental history was 0.27 (95% CI 0.12–0.42) for sexual abuse, 0.21 (95% CI 0.03–0.39) for physical abuse and 0.22 (95% CI 0.03–0.42) for emotional neglect. The ORs for these associations are shown in Table 3. The APs did not differ significantly from 0 for the other childhood maltreatments, suggesting that their role was independent of parental history of alcoholism.
