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Chunk #27 — Discussion — Limitations and Future Directions

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Who achieves low risk drinking during alcohol treatment? An analysis of patients in three alcohol clinical trials.
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with respect to psychiatric symptoms predicting drinking during treatment and the severity of AUD in the sample (particularly in the COMBINE participants). Additionally, the treatment period for COMBINE was 16 weeks, however only the first 12 weeks of data were analyzed in the current paper. Recent work examining the COMBINE data has indicated that most changes in drinking occur during the first 2–3 months of treatment[50], which is reflected in the time-period analyzed in the current study. Nonetheless, future research examining the full 16 week treatment period could further help elucidate predictors of drinking patterns during treatment in the COMBINE study.