at p < 0.05, concordant directions of effect, and meta analysis p-value less than the Bonferroni threshold in the discovery set. π1 is an estimate of proportion of true positives in the replication set. π1(all) uses all gene–tissue pairs whereas π1(sig) is computed using only gene-tissue pairs that were significant in the discovery set. The column ‘# replicated genes coloc or undeterm’ is the number of replicated genes excluding the ones for which there was strong evidence of independent GWAS and eQTL signals
