The NHGRI-EBI GWAS Catalog (www.ebi.ac.uk/gwas; (16)) is a publicly available resource of published human GWAS. Manual curation of each publication by expert scientists ensures that the Catalog provides accurate and structured metadata for publication, study design, sample and trait information and the most significant published results. Data extracted from publications is now augmented by full P-value SS, where available, through the publication or submitted by investigators. The Catalog's data have many applications, for example, to identify causal variants (17), understand disease mechanisms, analyse expression quantitative trait loci (eQTL) (18,19) and establish targets for novel therapies (8,20). In the last year the GWAS Catalog Graphical User Interface (GUI) has been accessed by approximately 90000 unique users and >1 million pages have been viewed, a 40% increase on the previous year. The full Catalog data have also been downloaded 23637 times in the last year with an additional 1281578 downloads of search results and 14653 of summary statistics.
