Genome-wide association studies (GWASs) have identified novel genes that might be associated with LOAD. Recently, SNP arrays have been developed and used for the analysis of several genes and SNPs. GWASs have been successfully applied to complex polygenic disorders, such as diabetes and macular degeneration.150,151 Several papers have been published on the association between AD and different genes or alleles. Bertram et al have created a publicly available, constantly updated, database summarizing the potential genes that may be related to AD (http://www.alzgene.org).152 Systematic meta-analyses were performed for each polymorphism with all genotype data described for them. At least three case-control samples were tested. This database collected all potential genes that may be involved in AD onset, thus is a powerful tool to further the understanding of AD genetics. Additionally, it may be considered a model for tracking gene candidates in other polygenic disorders.152,153
