Another high frequency area for the ALDH2*504Lys allele is Central Japan with 34.1% in Chiba. However, this high frequency area seems to be an extension from East China. The frequency decreases from around 30% in Honshu to around 10% in Ryukyu and Hokkaido, corresponding well to the migration history of modern Japanese (the descendants of Yayoi People, Hammer et al., 2006). Therefore, it is most probable that the ALDH2*504Lys allele in Japan was brought by the early Yayoi migrants from mainland East Asia.
