Results are summarized in Table II. In EAs, we detected a genome-wide significant linkage signal in chromosome 4 with a peak lod = 3.31 at 68.3 cM (point-wise P = 0.00005, empirical genome-wide P = 0.038). The 1-lod score support interval centered on this linkage peak extends from 66.6 to 74.02 cM. A suggestive linkage signal in chromosome 21 was also observed with a peak lod = 2.37 at 19.4 cM. In AAs, two suggestive linkage peaks were observed in chromosome 10 with a peak lod = 2.66 at 96.7 cM and a peak lod = 3.02 at 147.6 cM; these flank our previously reported linkage peak near 117.2 cM for alcohol dependence in AAs. In addition, another suggestive linkage region was identified in chromosome 3 with a peak lod = 2.81 at 145.5 cM and in chromosome 9 with a peak lod = 1.93 at 146.8 cM.
