Data were collected in 2007-2009 from 1,349 adult household residents (Shmulewitz et al., 2010; Shmulewitz et al., 2012). This study was designed to investigate environmental and genetic influences on alcohol-related traits; drinking among Israeli women has low prevalence, so males were oversampled (Hasin et al., 1998; Spivak et al., 2007; Shmulewitz et al., 2010). Interviewers received structured training and administered face-to-face computer-assisted interviews after obtaining written informed consent, as approved by relevant American and Israeli IRBs (Shmulewitz et al., 2010). The overall response rate was 68.9%. Quality control included field observation, reviews of recorded interviews, and telephone verification of responses. The association analysis included 1,129 ever-drinkers (drank any alcohol, lifetime) who were genotyped for the ADH1B and ADH1C SNPs. Of these, 25.2% (N=284) were 21-29 years old, 33.7% (N=380) were 30-44, and 41.2% (465) were 45+; 78.3% (N=884) were male; and 23.9% (N=270) were immigrants from the Former Soviet Union (FSU).
