To illustrate the SNP analysis process, we consider SNPs in the selectins, proteins involved in the early inflammatory response, playing a role in the accumulation of blood leukocytes at sites of inflammation. SNP analysis for relevant genes may be accessed by typing a disease or process name into the corresponding search window. Entering 'inflammation' returns a ranked list of genes with abstracts containing that term, hyperlinked to their SNP analysis pages. Entering a more specific search term, such as 'selectin' returns a list of relevant genes, including the members of the selectin family SELE, SELP and SELL, as well as proteins they interact with. Entering a specific gene name, such as SELE, takes the user directly to the analysis of SNPs in that protein. Figure 2 shows a composite of the screen information for some inflammation related SNPs in selectins E, P and L and VCAM1. Each of these SNPS is classified as deleterious by the sequence profile method (indicated by the negative SVM scores). The SNPs in SELE (C130W) and SELP (G179R) are also analyzed by the structure/stability model,
