Differences in the connectivity of large scale brain networks (“the connectome”) have been observed among individuals with neuropsychiatric disorders, including alcohol use disorders1 (AUD). While the development of MRI-based resting-state functional connectivity has profoundly improved our understanding of the spatial organization of human brain connectivity, it does not provide the real-time temporal resolution required to observe neural activity on the order of milliseconds at which neural communication for most relevant sensory, motor and cognitive phenomena in the brain occur that is provided by EEG functional connectivity2. One measure of EEG functional connectivity is EEG coherence, which measures the degree of synchrony in oscillatory activity between two brain regions, where increased coherence indicates functional integration between these brain regions and decreased coherence reflects unrelated neural activity3,4. EEG coherence provides detailed frequency specific measures of neural connectivity, enabled by the millisecond sampling rate of EEG recording. An advantage of EEG connectivity is the ability to assess local and distal connectivity patterns as a function of frequency band, as aspects of neural function and connectivity patterns between brain regions are specific to EEG
