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Chunk #41 — Discussion

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Brain expression quantitative trait locus and network analyses reveal downstream effects and putative drivers for brain-related diseases.
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We expect that this resource will prove valuable for post-GWAS brain research. Our dataset can be utilized to disambiguate GWAS loci, point to causal pathways and prioritize targets for drug discovery. We expect that through future integration with single-cell eQTL studies that have higher resolution but still lower power, our results will help to pinpoint transcriptional effects in specific brain cell types for many disease-associated genetic variants.