cohorts comprising African-American (AA; 6152 cases 3918 controls) and Latino (1234 cases, 3090 controls) participants; the combined sample is equivalent in power to 6,551 each of cases and controls. 1249 LD – independent (r2 > 0.1) Variants showing evidence for association (P< 1×10−5) were further meta-analysed with an additional dataset of 1,979 cases and 142,626 controls of European ancestry obtained from deCODE genetics, thus the final analysis represents 320,404 diploid genomes.