In summary, we implemented an efficient software package, SEQMINER, to facilitate the analysis and interpretation of genotype‐phenotype association summary statistics. We showed that the tools can scale well to large datasets with millions of variants. SEQMINER provides a useful platform where new methods can be developed and distributed. Since its release, the software package has contributed to several large‐scale meta‐analyses of complex traits, including lipid levels, height, and body mass index, as well as smoking and alcohol addictions. We envision that the software package will continue to be extremely valuable for interpreting genotype‐phenotype association results in the sequencing era.