In the iPSYCH2015 cohort25, we have added 11,710 depression cases and 18,410 controls to the iPSYCH2012 sample12,26, summarizing to a total of 34,095 cases and 45,393 controls prior to relatedness pruning and removal of ancestry outliers (Supplementary Table S14). A total of 30,618 cases and 38,200 controls were retained after relatedness pruning and removal of ancestry outliers. Of these, 6,517 had recurrent episodes of depression (see definition below), while 24,101 were classified as single-episode depression cases.