GABAA receptors are involved in mediating both the acute and chronic effects of alcohol (Kumar et al., 2009), and markers in GABA system genes have been associated in a number of studies with alcohol dependence and other alcohol-related phenotypes (Cui et al., 2012). We used multiple methods to interrogate the potential relationship between alcohol use and abuse phenotypes and variation in GABA system markers, either taken individually or aggregated using different methods, but no association was evident in any of them.
