Gene-based association and enrichment tests were performed using meta-analysis summary statistics in MAGMA. FLT3 was identified with genome-wide significant association after correcting for 18,079 gene tests (p=8.9×10−7) (Figure S10). The most significant SNP in the FLT3 locus, rs2504235, was the only SNP surpassing genome-wide significance threshold in the primary meta-analysis, and was significantly associated with FLT3 expression level both in cerebellum (p=6.5×10−10) and cerebral cortex (p=2.6×10−11)(28). No gene set was significantly associated with Tourette syndrome after Bonferroni correction. In the gene expression enrichment analyses of 53 adult human tissues, only dorsolateral prefrontal cortex (Brodmann area 9 (BA9)) demonstrated significant enrichment of Tourette-associated genes after correction (β=0.023, SE=0.0069, p=1.2×10−4) (Figure 3, Supplemental Methods).
