We then investigated enrichment for expression Quantitative Trait Loci (eQTL) that have been shown to alter expression of specific genes. These results allowed for the identification of likely target genes. These links are based on empirical associations between SNPs and gene expression rather than the clustering of SNPs based on genomic locations. This provides an important step in reducing the number of likely target genes affecting the investigated trait. Finally, we analyzed enrichment of significant genes in the available cerebral brain tissues of the GTEx database (Lonsdale et al., 2013). Using the same database, we examined how specific genes are expressed in specific brain tissues, further elucidating the pathway from genetic variation to brain activity.
