bodies” gene set was the most significant (P=0.0009), while for the one-step analysis, the most significant gene set was the “neuroactivated ligand-receptor interaction” pathway (P=0.008). Interestingly, many of the strongly associated SNPs in this gene set were in glutamate receptor genes, including GRIK1, which has been associated with AD (Kranzler et al., 2009) and the response to topiramate treatment for heavy drinkers (Kranzler, 2014).
