The effect sizes of lead variants in genome-wide significant loci of the T2D meta-GWAS were largely concordant between the European and East Asian populations (correlation of the absolute values of effect sizes across 271 variants: r = 0.67), while the effect sizes between the European and African populations were less concordant but still moderately correlated (correlation of the absolute values of effect sizes across 217 variants; r = 0.34), suggesting that the cross-ancestry genetic architecture of T2D is consistent with the modeling assumptions in PRS-CSx (Additional File 1: Fig. S3).
