50mM ethanol on complex spike area, suggesting that interaction with mGluR1 receptors may mediate the effect of ethanol observed in these cells. In support of this, 50mM ethanol inhibited mGluR1-dependent EPSCs recorded from Purkinje neurons in response to climbing fiber stimulation. Ethanol had no effect on AMPA receptor-mediated paired-pulse facilitation, however. Finally, these authors reported that 50mM ethanol inhibits synaptic plasticity at climbing fiber synapses.
