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Chunk #17 — Materials and Methods — Power of the study

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A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks.
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We conducted power calculations under an additive genetic model, at alpha = 5×10−8, assuming the trait SNP and marker are in complete linkage disequilibrium with specified D′, for a range of assumed effect sizes starting with the strongest effect identified in the present study, using the Genetic Power Calculator (Purcell et al. 2003).