Because the three genes are biologically related in terms of the functions of their encoded enzymes or pathways, genotype data of ADH1C was also analyzed. In this study, our findings strongly support that ADH1C 350Ile may lower the risk for AD and alcohol abuse as well as some alcohol-related diseases, particularly in Asian populations. Regarding the studies included in this meta-analysis, the prevalence of 350Ile allele varied greatly across these populations: from 40% in the Polish population to 100% in some Chinese aboriginal populations (e.g., Ami). Table 2 and Figure 5 show allele frequencies by geographic location.
